biological activity and efficient synthesis of 3, 4-dihydropyrimidin-2-(1h)-one/thione derivatives

Authors

farhad hatamjafari department of chemistry, faculty of science, islamic azad university, tonekabon branch, tonekabon, iran

abstract

the present study aimed to use a method for the synthesis of some 3, 4-dihydropyrimidin-2-(1h) - ones/thiones. the study tried to answer the question whether this reaction can be performed without solvent and with new catalyst or not. to find answer to the question, we described a novel protocol for the efficient synthesis of 3, 4-dihydropyrimidin-2-(1h)-one derivatives using aromatic aldehyde, ethylacetoacetate, and urea/thiourea under solvent-free conditions by using sio 2 -cacl 2 as a catalyst. using this catalyst has some advantages; it's high yields, usable in mild conditions, available, reusable, ecofriendly, cost effective and environmentally friendly. the structural features of the synthesized compounds were characterized by ir, 1 h nmr and 13 c nmr. the compounds were screened for antimicrobial activity. the results showed these compounds react against all the tested bacteria. we have demonstrated a novel method for the synthesis of substituted dihydropyrimidinones catalyzed by sio 2 -cacl 2 under solvent-free conditions.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

An Efficient Synthesis of 3,4-Dihydropyrimidin-2-(1H)-one Derivatives Promoted by Antimony Trichloride under Thermal and Solvent-free Conditions

An efficient and simple one-pot approach for the synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives using antimony trichloride (SbCl3) as a mild catalyst by means of three-component Biginelli reaction between β-keto esters, aldehyde derivatives and urea/thiourea under thermal and solvent-free conditions with excellent yields and short reaction times is reported. This m...

full text

Synthesis and Biological Activity of Certain Mannich Bases Derivatives from 1, 2, 4-Triazoles

Substituted 1, 2, 4- Triazoles have shown multiple biological activities such as anti-inflammatory, anti fungal, etc. 5-mercapto triazoles were prepared from the potassium dithiocarbazinates. These triazoles were used for preparation of different derivatives by two different schemes. In the first scheme the Mannich bases were prepared from 5- marcapto-s triazole Quinazolines. The 5-Marcato-s-Tr...

full text

Synthesis of 4-(2-Methylthiazol-4-yl)-Hexahydroquinoline and 1,4-Dihydropyrimidin Derivatives

A series of new hexahydroquinoline and 1,4-dihydropyrimidine derivatives were synthesized. Condensation of 2-methyl- thiazole-4-carboxaldehyde (1) with 1,3-cyclohexanedione and alkyl 3- aminocrotonate afforded 4-(2-methyl-thiazol-4-yl)-hexahydroquinoline while condensation of aldehyde (1) with benzoyl acetone and thiourea gave 1,4-dihydropyrimidine derivatives. The stereochemistry of 1,4-dihydr...

full text

Efficient Ce(NO3)3 x 6H2O-catalyzed solvent-free synthesis of 3,4-dihydropyrimidin-2(1H)-ones.

Cerium(III) nitrate hexahydrate efficiently catalyzes the three-component Biginelli reaction under solvent-free conditions of an aldehyde, a beta-keto ester or beta-diketone and urea or thiourea to afford the corresponding 3,4-dihydropyrimidin-2(1H)-ones or -thiones in excellent yields.

full text

(CTA)3[SiW12]-Li+-MMT: Efficient nanocatalyst for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones under solvent-free conditions

A highly practical and efficient preparation of 3,4-Dihydropyrimidin-2(1H)-one derivatives was developed via an efficient and simple nanocatalyst and promoted multi-component reaction of ethyl acetoacetate, aromatic aldehyde, and urea in the presence of a catalytic amount of (CTA)3[SiW12]-Li+-MMT under solvent-free conditions. In comparison to the conve...

full text

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 3-(2’-n-BUTYLBENZOFURAN-3’-YL)-5-ARYL-4, 5-DIHYDRO-1H-PYRAZOLES.

           3-(2’-n-butylbenzofuran-3’-yl)-5-aryl-4, 5-dihydro-1H-pyrazoles (4a-4k) have been synthesized. The synthesized products have been assayed for their antimicrobial activity against Gram+ve,      Gram-ve bacteria and fungi. All the synthesized products were assigned with IR, 1HNMR, Mass Spectra, TLC, and elemental analysis. Some of the products showed moderate activi...

full text

My Resources

Save resource for easier access later


Journal title:
journal of chemical health risks

جلد ۴، شماره ۴، صفحات ۰-۰

Keywords
[ ' a n t i m i c r o b i a l a c t i v i t i e s s i l i c a s u p p o r t e d c a l c i u m c h l o r i d e ( s i o 2 ' , ' c a c l 2 ) ' , 3 , 4 , ' d i h y d r o p y r i m i d i n ' , 2 , ' ( 1 h ) ' , ' o n e / t h i o n e ' , ' o n e ' , ' p o t ' , ' s o l v e n t ' , ' f r e e c o n d i t i o n s ' ]

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023